Requirement of IL-17RA in Con A induced hepatitis and negative regulation of IL-17 production in mouse T cells.
نویسندگان
چکیده
Th17 cells, a subset of T cells involved in autoimmunity and host defense against extracellular Gram-negative infection, express both IL-17A and IL-17F. Both IL-17A and IL-17F can signal via the IL-17RA; however, IL-17F does so at a 1- to 2-log higher concentration than IL-17A. In this study, we show that the IL-17F homodimer via IL-17RA is a negative regulator of IL-17 production in T cells and suggest a mechanism whereby IL-17RA on T cells serves as an autocrine/paracrine regulator of IL-17 synthesis in T cells.
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ورودعنوان ژورنال:
- Journal of immunology
دوره 181 11 شماره
صفحات -
تاریخ انتشار 2008